Tomoya Kujirai

This study shows that macroH2A1 and H3K27me3 bind cGAS to sequester it in heterochromatin, preventing innate immune activation.

The paper investigates how RNA polymerase II transcribes through an OLDN, finding higher efficiency from the hexasome side and revealing conformational changes during transcription.

The paper investigates how specific acetylation sites on histone H3 affect RNAPII transcription through nucleosomes using cryo-EM structures.

The paper reveals how Set2 deposits H3K36me3 on reassembled nucleosomes during transcription elongation using Cryo-EM structures of the EC-Set2-nucleosome complex.

This study reconstitutes gene-scale chromatin arrays with controlled histone modifications to show acetylation increases structural fluctuations and reduces nucleosome contact frequency.

This study shows that RNA polymerase II transcribes the H3-H4 octasome more efficiently than the nucleosome, with distinct pausing patterns and stepwise tetramer disassembly.

The paper introduces a cGAMP reporter to visualize cGAS activation in response to DNA damage and finds that cGAS activation is limited to a subfraction of cells and not correlated with micronuclear cGAS enrichment.

The paper identifies NSD2 and ISWI chromatin remodeling complexes as mediators of H3K36me2 enrichment in pericentromeric heterochromatin and shows its presence in early mouse embryos.

The paper tracks H3K27me3 and H4K20me1 dynamics during XCI and finds they accumulate concurrently but have distinct genomic distributions, with H4K20me1 possibly contributing to chromatin compaction.