Hitoshi Kurumizaka

This study shows that macroH2A1 and H3K27me3 bind cGAS to sequester it in heterochromatin, preventing innate immune activation.

The paper identifies that CC and GG dinucleotides at specific positions influence nucleosome positioning in yeast and mouse genomes by destabilizing histone-DNA interactions.

The paper investigates how RNA polymerase II transcribes through an OLDN, finding higher efficiency from the hexasome side and revealing conformational changes during transcription.

The paper investigates how specific acetylation sites on histone H3 affect RNAPII transcription through nucleosomes using cryo-EM structures.

This study maps chromatin accessibility and protamine incorporation during spermiogenesis, revealing compartment-specific dynamics and their role in genome stability.

The paper reveals how Set2 deposits H3K36me3 on reassembled nucleosomes during transcription elongation using Cryo-EM structures of the EC-Set2-nucleosome complex.

This study uses single-molecule optical tweezers to show that high-concentration, high-molecular-weight PEG promotes chromatin compaction by enhancing internucleosomal interactions.

This study reconstitutes gene-scale chromatin arrays with controlled histone modifications to show acetylation increases structural fluctuations and reduces nucleosome contact frequency.

This study shows that RNA polymerase II transcribes the H3-H4 octasome more efficiently than the nucleosome, with distinct pausing patterns and stepwise tetramer disassembly.

The paper identifies NSD2 and ISWI chromatin remodeling complexes as mediators of H3K36me2 enrichment in pericentromeric heterochromatin and shows its presence in early mouse embryos.

This study reveals how DDM1 remodels H2A.W nucleosomes in Arabidopsis, enabling chromatin writers to access heterochromatin for DNA methylation.

The paper introduces tsChIL, a method to analyze tissue-level epigenomic data from single-thin sections, enabling independent evaluation of cell population changes and gene activation in regenerating skeletal muscle.

The paper tracks H3K27me3 and H4K20me1 dynamics during XCI and finds they accumulate concurrently but have distinct genomic distributions, with H4K20me1 possibly contributing to chromatin compaction.