Richard O. C. Oreffo

The paper develops an ex vivo chick embryonic bone model using PLGA microparticles to study growth factor delivery effects on cell differentiation and tissue formation, showing that controlled release of BMP2 and FGF2 alters collagen deposition and cell morphology.

This paper uses SHG microscopy to quantify collagen fibre-length differences in human bone and osteosarcoma, showing reduced fibre lengths in OS compared to normal bone.

The paper develops novel biomolecular techniques to image and analyze orthopaedic trabecular metal implants, showing varying responses of human bone marrow stem cells to different implant designs.

This study evaluates bioactive coatings on 3D printed PCL-TMA900 scaffolds for bone regeneration using a murine femur defect model, finding that Laponite/BMP-2 coating significantly promotes bone formation without heterotopic bone formation.

This study evaluates bioactive coatings on 3D-printed PCL-TMA scaffolds for bone regeneration, showing in vitro osteogenic response but no significant in vivo bone formation.

This paper evaluates Laponite-coated scaffolds for delivering BMP-2 to enhance bone regeneration, showing effective osteoinduction in vitro and in vivo with delayed use.

This study evaluates Laponite(R)-coated scaffolds for delivering BMP-2 in a large animal bone defect model, showing enhanced bone formation compared to uncoated scaffolds.

This paper uses transfer learning to map biology from mouse to human bone marrow using single-cell RNA-sequencing data, showing improved accuracy with retraining and zero-shot learning.

This study shows nanotopography can control MSC immunomodulatory capacity by modulating intracellular tension and oxidative glycolysis, and identifies bioactive metabolites that influence MSC function.