Christopher A. Moxon

Antibiotic treatment of meningococcal and other sepsis causative bacteria triggers the release of histone-like proteins (HLPs) that damage the endothelium and drive coagulopathy, but these effects can be neutralized by non-anticoagulant heparins or anti-HLP antibodies.

This study shows that severe malarial anaemia is linked to increased red blood cell production, iron metabolism, tissue injury, and parasite biomass in bone marrow, with better resolution from bone marrow analysis than peripheral blood.

The paper presents a spatially resolved single-cell atlas of lung tissue from fatal Covid19 cases in an African population, revealing a distinct cellular signature and an interferon gamma-dominated response.

This study shows parasite histones contribute to coagulopathy and vascular leak in cerebral malaria, leading to brain swelling and poor outcomes.