Andrew J. Roe

Antibiotic treatment of meningococcal and other sepsis causative bacteria triggers the release of histone-like proteins (HLPs) that damage the endothelium and drive coagulopathy, but these effects can be neutralized by non-anticoagulant heparins or anti-HLP antibodies.

This paper shows that ME0054 disrupts AdhE spirosomes, enhancing ethanol-to-acetyl-CoA conversion and altering T3SS expression in EHEC.

The paper describes a low-cost 3D-printed optical microscope capable of sub-cellular resolution for histological imaging, using affordable components and open design for replication.

This study investigates aurodox's effect on T3SS in multiple Gram-negative pathogens, showing it inhibits some but not all T3SS systems, with selectivity observed across different strains.

The paper isolates and characterizes an E. coli O157:H7 strain from commercial specific-pathogen-free mice, revealing limitations in current screening systems.

This study enhances an artificial urine medium to support growth of UPEC strains and shows similar gene expression profiles compared to pooled human urine.

The paper reports the genome sequence of Streptomyces goldiniensis ATCC 21386, which produces the polyketide aurodox, and identifies biosynthetic gene clusters.

This study shows that D-serine induces distinct transcriptional responses in three Escherichia coli pathotypes, with no common differentially expressed genes across all strains.

The paper identifies a genomic inversion as the mechanism driving small colony variant formation and increased virulence in P. aeruginosa during chronic infection.