Alena Klochkova

This study identifies ANO6-mediated trogocytosis as a mechanism by which CAFs transfer lipids to PDAC cells, promoting tumor growth and immune suppression.

This study shows that influenza-induced tuft cell expansion interacts with ILC2s to regulate inflammation, with tuft cell deficiency altering ILC subsets and inflammatory responses.

The paper shows dysplastic basal cells induce an inflammatory fibroblast phenotype through IL-1 secretion, promoting chronic inflammation and fibrosis.

This study identifies IL-13 as a driver of increased mitochondrial mass in esophageal keratinocytes, impairing squamous cell differentiation and contributing to eosinophilic esophagitis.

This study shows that Type I Diabetes Mellitus worsens SARS-CoV-2-induced lung injury in mice by impairing immune responses and increasing inflammation.

The paper investigates autophagy's role in esophageal homeostasis, finding that high autophagic vesicle content in basal cells correlates with limited proliferation and enhanced self-renewal.

This study uses single-cell RNA sequencing to identify cellular diversity and age-related mitochondrial dysfunction in murine esophageal epithelium.

The paper shows that cholesterol deprivation activates TGFβ signaling, promoting basal differentiation in pancreatic cancer by stabilizing the TGFβ receptor.