Kelly A. Whelan

The paper uses scRNA-seq to compare IL-13-treated esophageal organoids with EoE biopsies, revealing shared cell state heterogeneity and differentiation hierarchy dysregulation.

This study shows that NIX-mediated mitochondrial remodeling is essential for esophageal epithelial differentiation and that its disruption may contribute to eosinophilic esophagitis.

This study shows that Prostaglandin E2 reverses myofibroblast differentiation in EoE via the cAMP/YAP/THBS-1 pathway, suggesting it as a potential treatment for fibrostenotic EoE.

This study identifies FOXM1 as a key driver of epithelial disruption in EoE, showing that its inhibition restores differentiation, reduces hyperplasia, and improves barrier function.

This study identifies IL-13 as a driver of increased mitochondrial mass in esophageal keratinocytes, impairing squamous cell differentiation and contributing to eosinophilic esophagitis.

This study shows that deleting Ikkβ in esophageal epithelial cells worsens eosinophilic esophagitis in a mouse model, highlighting the importance of IKKβ/NFκB signaling in preventing allergic inflammation.

The paper investigates autophagy's role in esophageal homeostasis, finding that high autophagic vesicle content in basal cells correlates with limited proliferation and enhanced self-renewal.

This study uses single-cell RNA sequencing to identify cellular diversity and age-related mitochondrial dysfunction in murine esophageal epithelium.

This study shows IMP1 regulates intestinal epithelial repair after irradiation and colitis by modulating autophagy through direct binding to autophagy transcripts.