Hao Jiang

CysNet infers cysteine redox proteoforms from mass spectrometry data, resolving oxiform states and quantifying their abundance in human stem cells.

This paper develops a workflow to identify proline hydroxylation sites using HILIC and LC-MS, finding 4,993 and 3,247 sites in HEK293 and RCC4 cells, respectively.

The paper shows DNA methylation maintenance is linked to lagging-strand replication and TE control in mouse cells, with TE integration preferentially occurring on the lagging strand.

ReCap enables redox proteomics by preserving redox states and scaling oxidation to protein copy numbers, revealing sparse and quantitatively concentrated cysteine oxidation signals.

This study shows DNA replication enables chromatin changes during human iPSC differentiation by allowing protein access to nascent DNA, with H3K9 methylation and proteins like ERH and SETDB1 playing key roles.

The paper identifies progesterone chemotactile receptors in octopus hectocotylus, showing their evolution from neurotransmitter receptors and role in mating.

This study identifies PHD1-dependent hydroxylation of RepoMan at P604, showing it regulates mitotic progression by modulating PP2A interaction and H3T3 phosphorylation.

This study shows that microbiomes on ecological surfaces activate octopus chemotactile receptors to guide behavior through distinct molecular signals.

This study compares the proteomes of human induced pluripotent stem cells (hiPSCs) and embryonic stem cells (hESCs), finding quantitative differences in protein expression affecting growth, metabolism, and secreted factors.

This study shows that deleting CD44 in preadipocytes promotes adipogenesis by suppressing PPARγ and cell cycle pathways, suggesting CD44 as a therapeutic target for obesity-related metabolic diseases.

This study identifies FAM111A as a regulator of DNA replication origin activation and shows its interaction with FAM111B and HMCES, with implications for disease when its peptidase domain is intact.

This study shows that transcription restart after DNA replication promotes chromatin reestablishment but is also linked to genotoxic stress.

The paper shows that erosion of X chromosome inactivation in human iPSCs leads to increased protein expression from X-linked and autosomal genes, altering protein-RNA correlations and increasing protein content.