Qi Hao

This study identifies declining Wnt signaling as a driver of age-related alveolar stem cell loss and shows that restoring Wnt signaling in aged mice improves lung repair but not full regeneration.

This paper shows that an eIF2B activator rescues neonatal lethality in a VWM mouse model but leads to age-related motor deficits and myelin loss.

The paper identifies a mechanism by which eIF2γ binding to PPP1R15A enhances catalytic efficiency of the holophosphatase that terminates the integrated stress response.

The paper designs a covalent peptide inhibitor, reactide, targeting the HPV16 E6-E6AP interaction to prevent p53 degradation.