Author
University of CambridgeORCID 0000-0002-7359-7974Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Fiona Shilliday, Miguel Gancedo-Rodrigo, Ginto George…·John E. Linley
The paper identifies a chemical inhibitor of eIF2B that activates the Integrated Stress Response by stabilizing an inhibitory complex with phosphorylated eIF2.
Ginto George, Heather P. Harding, Richard Kay…·Adriana Ordóñez
This study identifies SLC33A1 as a key regulator of ATF6 activation by ER stress, showing its role in metabolite transport and glycan processing.
Joanne Tung, Lei Huang, Ginto George…·Adriana Ordóñez
The paper uses a CRISPR/Cas9 screen to identify calreticulin as a repressor of ATF6α signaling in the unfolded protein response.
Yahui Yan, Maithili Shetty, Heather P. Harding…·David Ron
The paper identifies a mechanism by which eIF2γ binding to PPP1R15A enhances catalytic efficiency of the holophosphatase that terminates the integrated stress response.
Luke A. Perera, Andrew Tym Hattersley, Heather P. Harding…·Elisa De Franco
Alisa F. Zyryanova, Félix Weis, Alexandre Faille…·David Ron
The paper identifies an ISRIB-binding site in eIF2B using cryo-EM and CRISPR/Cas9, showing its role in regulating translation through an allosteric mechanism.