Sheila Francis

This study shows fisetin restores MYC expression in aged macrophages, improving their function and physical performance in older organisms.

Endothelial Twist1 drives partial and advanced endothelial-to-mesenchymal transition via PELP1 and AEBP1-COL4A1 signaling, increasing collagen and ACTA2+ cells to stabilize atherosclerotic plaques in male mice and human carotid arteries.

This study examines vascular function and cognitive performance in mouse models of Alzheimer's disease, atherosclerosis, and their combination, finding hemodynamic deficits in atherosclerosis mice and no differences in amyloid or plaque burden in mixed disease models.

This study examines macrophage phenotypes in carotid plaques and shows glucocorticoids can reprogram macrophages to reduce inflammation and lipid uptake, potentially stabilizing atherosclerotic plaques.

The paper examines locomotion-induced hemodynamic responses in different vascular compartments of the whisker barrel cortex in mice, finding an early HbT decrease in draining and meningeal veins.

This study assesses neurovascular coupling and cortical spreading depression in models of atherosclerosis and Alzheimer's disease, finding exacerbated neurovascular decline and increased amyloid-beta plaques in comorbid conditions.

The paper investigates neurovascular coupling in J20-hAPP mice under normobaric hyperoxia, finding enhanced cerebral blood volume and potential therapeutic implications for Alzheimer's disease.

This study shows that experimental atherosclerosis in mice leads to reduced cortical hemodynamics and neural activity, associated with neuroinflammation and neuronal loss.