Thomas C. Irving

This study compares the distribution of an EGFR-targeted antibody and affibody in pancreatic tumors relative to collagen using synchrotron diffraction, finding cetuximab shows stronger inverse correlations with collagen than ABY029.

This paper improves fiber diffraction pattern alignment by refining symmetry center and rotation using hybrid methods, achieving accuracy comparable to exhaustive search with faster runtime.

This paper uses polarized second-harmonic generation microscopy to analyze myosin states in hypertrophic cardiomyopathy, showing increased ON state fraction in mutated tissue.

This study compares the structural and functional properties of porcine left atrial and ventricular myosin filaments, revealing distinct calcium-dependent regulatory mechanisms between the two chambers.

This study examines how mavacamten affects skeletal muscle structure by reducing ON-state myosin heads and shortening thin filament length, similar to its effects in cardiac muscle.

This paper shows Aficamten inhibits cardiac myosin ATPase without changing thick filament structure, unlike Mavacamten, leading to similar force reduction but different kinetic effects.

This study investigates the effects of MyBP-C knockout in skeletal muscle, finding altered length-dependent activation and myofilament structure, with implications for MyBP-C-related diseases.

The paper investigates how titin-based forces affect cardiac myofilament structures under stretch, supporting the Frank-Starling mechanism.

This study decouples structural OFF/ON states from biochemical SRX/DRX states in myosin using X-ray diffraction and ATP assays in porcine myocardium.

This study identifies sMyBP-C's critical role in skeletal muscle development and function using gene-edited mouse models, showing its necessity for prenatal and postnatal muscle growth and structural integrity.

This study shows that MyBP-CC1C7 domains form C-links and stabilize myosin OFF states, affecting crossbridge kinetics and sarcomere function.