Wilhelm Vaysse-Zinkhöfer

The paper identifies BCL2 proteins as co-receptors for CUL5WSB2 to target BIM for degradation, revealing a novel mechanism in apoptosis regulation with therapeutic implications for neuroblastomas and cancers.

The paper shows that male-specific protection against Myc-driven B-cell lymphomas is lost in mice lacking alternatively spliced p53 isoforms, identifying Ackr4 as a prognostic factor.

This study shows that using Cas9 to induce a double-strand break at CTG trinucleotide repeats leads to chromosomal rearrangements, highlighting risks of using Cas9 near microsatellites.