Franck Toledo

This study shows that the p53Y217C mutation causes inflammation, leading to oncogenic effects in male mice and teratogenic effects in female mice, with anti-inflammatory treatment improving female survival.

The paper shows that male-specific protection against Myc-driven B-cell lymphomas is lost in mice lacking alternatively spliced p53 isoforms, identifying Ackr4 as a prognostic factor.

The paper identifies 151 p53-DREAM target genes associated with blood or brain abnormalities through transcriptomic analysis and ChIP-seq data.