Author

Jonathan Chan

Cleveland ClinicORCID 0000-0001-6939-9943Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Jonathan Chan1 paper · University of Cambridge

Biology Disciplines

Click to filter author papers

Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 2

Frequent Co-Authors

Anand BhushaniD· 2 shared Belinda B. WillardiD· 2 shared Connie K. P. TamiD· 2 shared Yan SuniD· 2 shared Fariba Ghiamati YazdiiD· 1 shared Geeng-Fu Jang· 1 shared Jack S Crabb· 1 shared John W. Crabb· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCell Biology

Anand BhushanORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Cell BiologybioRxivPreprintJan 4, 2024

Epithelial cytokeratin 6a restricts secretory autophagy of proinflammatory cytokines by interacting with Sec16A

Anand Bhushan, Jonathan Chan, Yan Sun…·Connie K. P. Tam

This study shows that K6a restricts secretory autophagy of proinflammatory cytokines by interacting with Sec16A, reducing cytokine secretion in corneal epithelial cells.

1 citation

mouseproteomics

𝕏 PostBluesky

ImmunologybioRxivPreprintOct 24, 2023

Keratin 6a attenuates Toll-like receptor-triggered proinflammatory response in corneal epithelial cells by suppressing ELKS/IKKϵ-dependent activation of NF-κB

Jonathan Chan, Yan Sun, Anand Bhushan…·Connie K. P. Tam

This study shows that keratin 6a suppresses TLR-triggered inflammation in corneal epithelial cells by modulating ELKS/IKKε-dependent NF-κB activation, preventing excessive cytokine and chemokine production.

1 citation

mouseproteomics

𝕏 PostBluesky