PhysiologyThe FASEB JournalPeer-reviewed
Histone Deacetylase Inhibitors Prevent Cytokine-Induced β Cell Dysfunction Through Restoration of Stromal Interaction Molecule 1 Expression and Activation of Store-Operated Calcium Entry
Chih‐Chun Lee, Tatsuyoshi Kono, Farooq Syed…·Carmella Evans‐Molina
This study shows that HDI sodium butyrate improves β cell function and calcium signaling in diabetes by restoring STIM1 and SOCE, and inhibiting GSK-3 through AKT.