Tatsuyoshi Kono

This study shows that GPER signaling maintains β cell identity in female mice, and its loss during menopause may contribute to β cell dysfunction and T2D risk.

This study shows that HDI sodium butyrate improves β cell function and calcium signaling in diabetes by restoring STIM1 and SOCE, and inhibiting GSK-3 through AKT.

This study shows cigarette smoke exposure impairs β-cell function through oxidative stress and ceramide accumulation, with effects persisting after smoking cessation.