Farooq Syed

This study identifies soluble LAG-3 (sLAG-3) as an early biomarker of T cell activation in type 1 diabetes, detectable before islet autoantibody development and associated with beta-cell stress and high-risk HLA genotypes.

This study shows that TYK2 inhibitors reduce islet inflammation and delay type 1 diabetes onset in mice by modulating immune and endocrine responses.

This study shows that miR-146a-5p overexpression in beta cells under inflammatory stress causes mitochondrial dysfunction and apoptosis, while its inhibition reverses these effects.

This study shows that HDI sodium butyrate improves β cell function and calcium signaling in diabetes by restoring STIM1 and SOCE, and inhibiting GSK-3 through AKT.

The paper identifies altered protein translation and carboxylic acid catabolism in diabetic kidney disease using human and mouse models.

This study uses single-cell RNA sequencing to define the temporal cellular and molecular changes in the kidney during sepsis, identifying key gene expression shifts and communication failures that mark critical points in the sepsis timeline.

The paper investigates lipid composition changes in insulitis models and identifies ARH3 as a regulator of beta-cell apoptosis through PLA2G6 signaling.