Jing Liu

This study shows that SCN2A deficiency in human brain assembloids disrupts cortico-striatal circuitry by impairing axonal projections and synaptic transmission, leading to hyperexcitability.

This paper introduces a method using SPAD arrays to count fluorophores in widefield microscopy by modeling PCH statistics and performing Bayesian inference.

This paper introduces a variational diffusion model for uncertainty-aware localization in single-molecule microscopy, enabling high-fidelity super-resolution and uncertainty estimation.

This study shows BRD4 phosphorylation affects chromatin nanodomain structure through its binding activity, influencing nucleosome dynamics and chromatin organization.

This study shows that TYK2 inhibitors reduce islet inflammation and delay type 1 diabetes onset in mice by modulating immune and endocrine responses.

This study shows that HDI sodium butyrate improves β cell function and calcium signaling in diabetes by restoring STIM1 and SOCE, and inhibiting GSK-3 through AKT.

This study investigates how cholesterol affects actin dynamics and cell adhesion in trabecular meshwork cells, showing that cholesterol modulates PIP2 levels and integrin distribution, thereby influencing cell stiffness and intraocular pressure.