Tatsuya Osaki

This study develops MosaicoidX to analyze MECP2 mosaicism in human cortical organoids, revealing spatial organization and functional connectivity differences between wild-type and mutant cells.

CHARIOT-AAV conjugates diverse vectors to AAVs to enable tissue-specific delivery and expanded cargo capacity for large genes.

This study examines how different MeCP2 mutations affect neuronal activity and network function in Rett syndrome organoids, finding mutation-specific impairments in connectivity and gene expression.

This study investigates vascular impairment in Rett syndrome by analyzing patient-derived endothelial cells and identifies miR126-3p as a mediator of vascular dysfunction.

This study shows that polyploidy in MDA-MB-231 breast cancer cells increases extravasation through enhanced cell-matrix adhesion.

The paper shows that cortical astrocytes mediate learned behavior by extending norepinephrine signals through calcium dynamics and ATP release, influencing neuronal encoding of task variables.

This study shows that the A53T mutation in α-synuclein increases pro-inflammatory activation and oxidative stress in human microglia, potentially contributing to early-onset Parkinson's disease.

The paper develops mito-FUNCAT-FACS to measure mitochondrial translation activity in individual cells and detects heterogeneity in cancer cells.

This study identifies SFSV NSs as a viral protein that suppresses the integrated stress response by binding to eIF2B and preventing eIF2(P) from inhibiting nucleotide exchange.

This study shows that reciprocally connected human cerebral organoids exhibit more complex and plastic neural activity compared to conventional organoids.

This study identifies Hero proteins as heat-resistant proteins that stabilize other proteins and prevent aggregation, extending lifespan in Drosophila.