Yoshiho Ikeuchi

This study shows that three-organoid networks exhibit better stimulus decoding after repetitive stimulation compared to smaller networks.

The paper introduces BioemuS, a real-time biomimetic spiking neural network system for biohybrid experiments and emulation, aiming to advance neuroprosthetic development.

This study identifies a functional interaction between MeCP2 and TOP2β in neurons, showing MeCP2 inhibits TOP2β activity at long genes, which may contribute to neurodevelopmental disorders.

This paper introduces methods to absolute quantify ribosome flux on transcripts, revealing ribosome allocation under stress, aging, and across cell types.

This study identifies ARID1B's role in axon projection of callosal projection neurons, showing its haploinsufficiency leads to structural underconnectivity and agenesis of the corpus callosum.

The paper develops mito-FUNCAT-FACS to measure mitochondrial translation activity in individual cells and detects heterogeneity in cancer cells.

This study identifies SFSV NSs as a viral protein that suppresses the integrated stress response by binding to eIF2B and preventing eIF2(P) from inhibiting nucleotide exchange.

This study shows that reciprocally connected human cerebral organoids exhibit more complex and plastic neural activity compared to conventional organoids.

This study identifies Hero proteins as heat-resistant proteins that stabilize other proteins and prevent aggregation, extending lifespan in Drosophila.