Sevan Hopyan

This paper introduces light sheet elastography to map tissue stiffness in embryos, enabling noninvasive, high-resolution analysis of mechanical changes during development.

The paper shows that fibronectin-dependent tissue stiffness controls durotaxis and cell rearrangements through a phase transition model in mouse limb bud mesoderm.

This study identifies the role of mesenchymal Wnts in regulating morphogenetic movements of calvarial osteoblasts during apical expansion in mouse embryos.

This study shows that graded Fibronectin (FN1) cues guide calvarial osteoblast migration and suture patency, with disruptions in FN1 or related pathways causing craniosynostosis in mice.

The paper shows that stochastic fluctuations and entropy, not stiffness gradients, drive neural crest cell ingression in mice.

This study uses single-cell RNA-sequencing to show that pulmonary mesenchyme in embryonic mouse lungs lacks distinct progenitors and instead forms a continuum of cell identities regulated by Wnt signaling.

This study develops a YAP fusion reporter mouse line and uses live imaging to analyze YAP localization dynamics during mouse embryonic development.

The paper introduces a 3D magnetic device to measure tissue stiffness in mouse embryos, revealing an anterior stiffness gradient that guides cell movement during limb bud development.

The paper shows that oscillatory cortical forces drive 3D cell intercalations in the mouse mandibular arch, shaping embryonic structures through Wnt5a, YAP/TAZ, and PIEZO1.