Author

Senem Aykul

Regeneron (United States)ORCID 0000-0001-7250-2913Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Aris N. EconomidesiD· 2 shared Erich J. GoebeliD· 2 shared Vincent J. IdoneiD· 2 shared Warren W. HomiD· 2 shared Erik Martı́nez-HackertiD· 1 shared John B. Lees‐ShepardiD· 1 shared Jordan Maust· 1 shared Kaitlin N. LydoniD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersBiochemistry

Aris N. EconomidesORCID

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3 papers

Recent·Most cited

BiochemistryProceedings of the National Academy of SciencesPeer-reviewedAug 25, 2025

CryoEM structure of ALK2:BMP6 reveals distinct mechanisms that allow ALK2 to interact with both BMP and Activin ligands

Erich J. Goebel, Senem Aykul, Warren W. Hom…·Vincent J. Idone

This paper presents the cryoEM structure of ALK2:BMP6, revealing distinct mechanisms for ALK2's interaction with BMP and activin ligands.

2 citations

cryo-EMexperimental assay

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Cell BiologybioRxivPreprintJan 29, 2024

Coordinate regulation of Activin and Bone Morphogenetic Protein signaling by a lysosomal trafficking switch

Warren W. Hom, Senem Aykul, Lampros Panagis…·Aris N. Economides

The paper shows that ActA forms non-signaling complexes with ACVR1 that are trafficked to lysosomes and degraded, unlike Activin B, AC, and AB which remain on the surface.

1 citation

humanexperimental assay

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Molecular BiologybioRxivPreprintMar 12, 2020

TGF-β Family Inhibitors Blunt Adipogenesis Via Non-Canonical Regulation Of SMAD Pathways

Senem Aykul, Jordan Maust, Monique Floer, Erik Martı́nez-Hackert

The paper investigates how TGF-β family inhibitors regulate adipogenesis by modulating SMAD pathways in 3T3-L1 cells, identifying mechanisms that suppress adipocyte formation.

5 citations

statistical modelexperimental assay

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