Author

John B. Lees-Shepard

Regeneron (United States)ORCID 0000-0002-1275-5799Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Aris N. EconomidesiD· 1 shared David J. GoldhameriD· 1 shared Erich J. GoebeliD· 1 shared Jeffrey W. Hunter· 1 shared Julian Chandler· 1 shared Kaitlin N. LydoniD· 1 shared Keith Bouchard· 1 shared Krunal PateliD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCell Biology

Aris N. EconomidesORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintJan 29, 2024

Coordinate regulation of Activin and Bone Morphogenetic Protein signaling by a lysosomal trafficking switch

Warren W. Hom, Senem Aykul, Lampros Panagis…·Aris N. Economides

The paper shows that ActA forms non-signaling complexes with ACVR1 that are trafficked to lysosomes and degraded, unlike Activin B, AC, and AB which remain on the surface.

1 citation

humanexperimental assay

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Developmental BiologyJournal of Clinical InvestigationPeer-reviewedMay 3, 2022

An anti-ACVR1 antibody exacerbates heterotopic ossification by fibro/adipogenic progenitors in fibrodysplasia ossificans progressiva mice

John B. Lees-Shepard, Sean J. Stoessel, Julian Chandler…·David J. Goldhamer

This study shows that an anti-ACVR1 antibody worsens heterotopic ossification in FOP mouse models by altering fibro/adipogenic progenitor behavior.

39 citationstop 2%

mouseexperimental assay

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