Alyssa H. Hasty

This study shows that voluntary exercise during weight loss reduces adipose CD8+ T cell exhaustion, which persists even after weight regain, but does not improve glucose tolerance or macrophage inflammation.

This study shows that blocking the CD70-CD27 axis reduces memory T cells and improves glucose tolerance in mice undergoing weight cycling.

This study shows that CD163 deficiency in obese male mice worsens insulin sensitivity by promoting inflammation and iron dysregulation in adipose tissue macrophages.

This study shows that thermoneutral temperature reduces energy expenditure and insulin-mediated glucose fluxes in mice, while insulin-independent glucose uptake in brown fat adjusts to temperature changes without compromising glucose homeostasis.

The paper identifies a novel lipid-associated mast cell population in weight-cycled mice and humans, linked to weight variance and potential disease roles.