Matthew A. Cottam

This study shows that voluntary exercise during weight loss reduces adipose CD8+ T cell exhaustion, which persists even after weight regain, but does not improve glucose tolerance or macrophage inflammation.

This study shows dehydration increases intracellular lipid synthesis and accumulation by promoting glutamine oxidation and mitochondrial metabolic remodeling.

This study shows that blocking the CD70-CD27 axis reduces memory T cells and improves glucose tolerance in mice undergoing weight cycling.

This study shows that impaired oxidative phosphorylation, driven by NDUFA4L2, promotes EMT and metastasis in renal cell carcinoma by altering chromatin accessibility.

This study shows caloric restriction enhances beta cell identity and homeostasis, delays aging and senescence, and improves mitochondrial function in pancreatic beta cells.

This study shows that Gli2 overexpression in dedifferentiated liposarcoma cells reduces adipogenic differentiation, increases osteoblast markers, and promotes an immunosuppressive myeloid phenotype in tumors.

The paper investigates how photoperiod affects SCN gene expression in mice, identifying key genes and pathways involved in circadian plasticity.

The paper identifies a novel lipid-associated mast cell population in weight-cycled mice and humans, linked to weight variance and potential disease roles.