Nathan C. Winn

QuantEM provides a vision transformer-based platform for EM data segmentation and analysis, achieving accurate zero-shot segmentation with less data than existing models.

This study shows that voluntary exercise during weight loss reduces adipose CD8+ T cell exhaustion, which persists even after weight regain, but does not improve glucose tolerance or macrophage inflammation.

This study shows that blocking the CD70-CD27 axis reduces memory T cells and improves glucose tolerance in mice undergoing weight cycling.

This study shows that Parvin in skeletal muscle is essential for insulin-stimulated glucose uptake and mitochondrial function, while having little effect on liver insulin sensitivity.

This study shows that sildenafil enhances microvascular adaptations to exercise training in obese mice, independent of endothelial nitric oxide synthase function.

This study shows that inhibiting purine biosynthesis with mizoribine prevents weight gain and improves metabolic health in mice on a high-fat diet by increasing thermogenesis and reducing food intake.

This study shows that endothelial β1 integrins are essential for microvascular function and glucose uptake during insulin stimulation.

This study shows that thermoneutral temperature reduces energy expenditure and insulin-mediated glucose fluxes in mice, while insulin-independent glucose uptake in brown fat adjusts to temperature changes without compromising glucose homeostasis.