Author
Leiden University Medical CenterORCID 0000-0001-7336-2887Unclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
4 papers
Recent·Most cited
Marta San Martín Alonso, Rosalie A. Kampen, Anne Schreuder…·Sylvie M. Noordermeer
The paper identifies a DNA damage- and phospho-dependent interaction between BRCA1 exon 11 and TOPBP1, showing its role in end-resection during homologous recombination.
Nadia Cobo‐Vuilleumier, Silvia Rodríguez-Fernández, Livia López–Noriega…·Benoit R. Gauthier
This study shows that activating LRH-1/NR5A2 reduces inflammation in T1D by altering immune cell metabolism and improves human islet function in mice.
Daniel Salas‐Lloret, Néstor García‐Rodríguez, Emily Soto-Hidalgo…·Román González‐Prieto
The paper identifies PCNA as a substrate of BRCA1/BARD1 ubiquitin E3 activity, showing it promotes replication fork stability and continuous DNA synthesis without requiring Homologous Recomberation or Olaparib resistance.
Daniel Salas‐Lloret, Nicolette S. Jansen, Easa Nagamalleswari…·Román González‐Prieto
The paper introduces SATTs to identify E3-specific SUMO substrates, finding 1681 SUMO substrates across eight E3s with distinct preferences.