Román González‐Prieto

This study identifies RNF25 as an E3 ubiquitin ligase that maintains genome integrity by modulating DNA replication, transcription, and translation through ubiquitin-mediated clearance of key proteins.

The paper identifies a DNA damage- and phospho-dependent interaction between BRCA1 exon 11 and TOPBP1, showing its role in end-resection during homologous recombination.

This paper identifies co-receptors for a parasite TGFβ antagonist, uses structural data to design cell-type-specific TGFβ modulators, and demonstrates their selective antagonistic effects.

This study identifies BCLAF1 as a regulator linking RNA splicing to ATF4-dependent metabolic adaptation in AML, showing its role in sustaining leukemic cell survival and sensitivity to venetoclax.

The paper identifies miRNA-mediated cell-to-cell communication via extracellular vesicles that enhances DNA repair during the radioadaptive response.

This study shows the NSL complex prevents R-loop induced replication stress during neural development, leading to developmental abnormalities when disrupted.

PLAMseq identifies genomic loci and protein interactors in a single workflow, validated for RNA polymerase II and CTCF, and applied to study histone H1 SUMOylation.

This study shows that activating LRH-1/NR5A2 reduces inflammation in T1D by altering immune cell metabolism and improves human islet function in mice.

This study shows that Lrif1 interacts with Trim28 to repress Dux in mouse embryonic stem cells, linking it to FSHD2 pathogenesis.

This study shows SUMOylation of SMCHD1 regulates its function at different genomic loci, affecting chromatin structure and DUX4 expression in FSHD.

The paper identifies PCNA as a substrate of BRCA1/BARD1 ubiquitin E3 activity, showing it promotes replication fork stability and continuous DNA synthesis without requiring Homologous Recomberation or Olaparib resistance.

The paper compares phosphoproteomes of primary and metastatic uveal melanoma cell lines to identify altered signaling pathways and potential drug targets.

The paper introduces SATTs to identify E3-specific SUMO substrates, finding 1681 SUMO substrates across eight E3s with distinct preferences.

The paper investigates how sumoylation modifications regulate EME1-MUS81 functions in CPT-induced rDNA repair by analyzing variants and interactomes.

The paper shows that UBC9 sumoylation enhances cell survival during CPT treatment by promoting EME1 sumoylation, which aids in ribosomal DNA repair.

This study identifies ELOF1 as a factor that directs CRL4CSA to ubiquitylate RNAPII at K1268, facilitating TCR and protecting CSB-deficient cells from transcription-replication collisions.

This study defines the sequential and cooperative assembly mechanism of the TCR complex and reveals how TFIIH is recruited to DNA damage-stalled RNAPIIo.