Jiahn Choi

The paper investigates zinc homeostasis in senescent intestinal epithelial cells, finding increased zinc levels and transporter dysregulation, with chelation reducing senescence markers.

This study shows how a Western-style diet alters gut microbiota and sulfur metabolism in mice, linking these changes to increased cancer risk and similar patterns in human colorectal cancer patients.

The paper shows that secretory cell lineages, not stem cells, can trigger tumor formation in the context of inflammation and Western-style diets, which are major colon cancer risk factors.

The paper shows that EOGT and O-GlcNAc glycans provide residual Notch signaling, enabling viability in mice lacking Pofut1 in the intestine.