Santosh Karnewar

The paper introduces a mouse model of advanced atherosclerosis that exhibits spontaneous plaque rupture leading to MI or stroke, and shows that MPO inhibition with AZM198 reduces mortality and plaque rupture incidence.

This study shows that inhibiting IL-1β in mice reduces the beneficial effects of diet-induced lipid lowering on atherosclerosis, increasing plaque burden and decreasing plaque stability.

The paper identifies sex-stratified gene regulatory networks in atherosclerotic plaques, showing female plaques are enriched with myofibroblast-like smooth muscle cell networks.