Author
Christiana Lekka
University of ExeterORCID 0000-0003-0188-7590Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2023-2026 · peak 3/yrCo-Author Collaboration Network
10 top collaborators · 28 mutual co-author links5 papers
Recent·Most cited
- PathologybioRxivPreprint✦ In-depth digest
Small things matter: Lack of extra-islet beta cells in Type 1 diabetes
Kathryn Murrall, Teifion Luckett, Christiana Lekka…·Sarah J. Richardson
Image analysis of 262,832 pancreatic endocrine objects across 220 donors reveals that small beta-cell-only clusters are abundant in early childhood but virtually absent in type 1 diabetes.
- Cell BiologybioRxivPreprint
GGA2-depletion in beta cells by Enteroviruses causes Golgi acidification, premature activation of cathepsins and alters the MHC class I immunopeptidome
Klaus-Peter Knoch, Antonia Kosok, Zuzana Mariničová…·Michele Solimena
This study shows that EVs deplete GGA2 in beta cells, causing Golgi acidification and altering the MHC class I immunopeptidome through premature cathepsin activation.
1 citation - ImmunologyNature CommunicationsPeer-reviewed
Interferon-α promotes neo-antigen formation andpreferential HLA-B-restricted antigen presentation in pancreatic β-cells
Alexia Carré, Fatoumata Samassa, Zhicheng Zhou…·Roberto Mallone
This study shows that IFN-α increases HLA-B-restricted antigen presentation in pancreatic β-cells, potentially influencing T1D pathogenesis.
42 citationstop 1% - NeurosciencebioRxivPreprint
Validation of Tau Antibodies for Use in Western Blotting and Immunohistochemistry
Michael J. Ellis, Christiana Lekka, Hanna Tulmin…·M. Irina Stefana
This paper evaluates 53 Tau antibodies for Western blot and immunohistochemistry, identifying those with high specificity and sensitivity for detecting Tau, including low-level and modified forms.