Jesse Boumelha

This study identifies the role of mature dendritic cells type 1 in forming, maintaining, and functioning tertiary lymphoid structures in cancer.

This study links oncogenic RAS activity to immune priming and adenosine-driven immune evasion in lung adenocarcinoma, showing both pro-immunogenic and immunosuppressive effects.

This study identifies conserved neoantigens across species and tissues that elicit strong immune responses and suppress tumor growth through vaccination.

This paper shows that combining RASG12C(ON) and SHP2 inhibitors can make cold lung tumors responsive to immune checkpoint blockade by altering the tumor microenvironment and enhancing anti-tumor immunity.

The paper benchmarks deconvolution tools for spatial transcriptomic data and introduces a novel pipeline to analyze tissue microenvironment dynamics.

This paper shows that AXL inhibits cholesterol mobilization in dendritic cells, which is necessary for their maturation and immunogenic response to cancer.