Christophe Desterke

This study shows that CBX3 deletion increases ROS and lipid ROS levels in CRC cells, sensitizing them to ferroptosis by disrupting the IFNγ/SLC7A11/SLC3A2 axis.

The paper identifies a signaling axis involving SorLA, integrin, and HER2/HER3 that regulates apicobasal polarity in mucinous colorectal adenocarcinoma and shows its therapeutic relevance.

This study shows a new auxotrophic Pseudomonas aeruginosa vaccine strain induces Th17 and IgA responses, offering mucosal protection against infection.

The paper identifies cells with hematopoietic stem cell (HSC) transcriptome features in human fetal kidneys and iPSC-derived kidney organoids.

This paper describes a method to convert adult hepatocytes into LGR5+ endodermal progenitor cells using transcription factors and activators, enabling liver tissue regeneration and disease modeling.

The paper generates c-met-mutated iPSC-derived kidney organoids that recapitulate genomic and phenotypic features of PRCC, identifying common genes and validating their expression in both organoids and patient tumors.