Bennett Davenport

This study identifies EIDD-3525 as a broad-spectrum antiviral against alphaviruses that inhibits RNA replication by targeting the nsP4 polymerase.

The paper identifies a unique transcriptional program in lymphatic endothelial cells that predicts antigen archiving capacity and validates it across datasets and in vivo.

This study uses deep mutational scanning of CHIKV E3/E2 glycoprotein mutants to identify amino acid preferences and predict viral escape mutants against neutralizing antibodies.

This study shows CHIKV infection disrupts lymph node lymphatic endothelial cell composition and function through MARCO interactions, leading to impaired antigen acquisition and increased inflammation.

This study shows that helpless CD8+ memory T cells, which form without CD4+ help, have transient functional impairments due to prolonged antigen exposure, which resolve over time.