Thomas E. Morrison

This study identifies EIDD-3525 as a broad-spectrum antiviral against alphaviruses that inhibits RNA replication by targeting the nsP4 polymerase.

This paper develops a computational pipeline to identify conserved antiviral target sites in alphaviruses using AI-driven methods, validating potential drug targets through mutagenesis.

The paper identifies a unique transcriptional program in lymphatic endothelial cells that predicts antigen archiving capacity and validates it across datasets and in vivo.

This study shows that epithelial nitric oxide synthase 2 (Nos2) influences host-microbiota interactions in IBD by regulating intestinal nitrates and nitrate-metabolizing bacteria, with implications for disease management.

This study identifies a first-in-class inhibitor of alphavirus nsP2 helicase activity, showing broad antiviral activity and in vivo efficacy against chikungunya virus.

This study uses deep mutational scanning of CHIKV E3/E2 glycoprotein mutants to identify amino acid preferences and predict viral escape mutants against neutralizing antibodies.

This paper identifies and optimizes oxaspiropiperidine inhibitors targeting nsP2hel, showing nanomolar antiviral activity against multiple alphaviruses.

This study shows that Chikungunya virus (CHIKV) nonstructural protein 2 (nsP2) disrupts MHC-I antigen presentation in infected fibroblasts, enabling immune evasion.

This study shows CHIKV infection disrupts lymph node lymphatic endothelial cell composition and function through MARCO interactions, leading to impaired antigen acquisition and increased inflammation.

The paper introduces dsRNA-Seq, a method to identify RNA viruses by sequencing double-stranded RNA, and demonstrates its effectiveness in detecting viral infections in mammals and reptiles.