Michael F. Good

The paper shows that sub-clinical exposure to Streptococcus pyogenes generates functional immune responses and contributes to immunity by adulthood.

This study investigates low-dose interleukin 2 (LD-IL-2) as an immunotherapeutic intervention in a rat model of acute rheumatic fever, showing reduced cardiac inflammation and increased regulatory T-cells.

The paper examines antibody responses to S. pyogenes antigens in individuals with and without pharyngitis, finding differences in IgG and IgA levels and correlations with prior immunity.

This study shows that IL-17 deficiency in mice leads to increased S. pyogenes dissemination after respiratory infection, contributing to invasive streptococcal disease.