Author

Sarah J. Horton

Wellcome/MRC Cambridge Stem Cell InstituteORCID 0000-0001-8418-5783Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Brian J.P. HuntlyiD· 3 shared Dhoyazan AzaziiD· 3 shared Ryan J. AsbyiD· 3 shared George GiotopoulosiD· 2 shared Jaana BagriiD· 2 shared Nathalie SakakiniiD· 2 shared Pedro MadrigaliD· 2 shared Shuchi Agrawal SinghiD· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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3 shared papersCancer Biology

Brian J.P. HuntlyORCID

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3 papers

Recent·Most cited

Cancer BiologyNature CommunicationsPeer-reviewedMay 20, 2025

Genetic or pharmacological inactivation of CREBBP sensitizes B-cell Acute Lymphoblastic Leukemia to Ferroptotic Cell Death upon BCL2 Inhibition

Alicia Garcia-Gimenez, Jonathan E. Ditcham, Dhoyazan Azazi…·Simon E. Richardson

This study identifies CREBBP mutations as a targetable vulnerability in B-ALL, showing that CREBBP inhibition sensitizes these cells to Venetoclax-induced ferroptosis.

19 citationstop 1%

humanbulk RNA-seq

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Molecular BiologybioRxivPreprintJan 27, 2025

Delayed Trp53 activation protects Dnmt3a-mutant hematopoietic stem cells from inflammatory attrition.

Ludovica Marando, George Giotopoulos, Pedro Madrigal…·Brian J.P. Huntly

This study shows that DNMT3A R882H mutant HSCs resist inflammatory stress through delayed p53 activation, leading to clonal expansion and increased AML risk.

DOI 10.1101/2025.01.27.635076

mousebulk RNA-seq

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Cancer BiologybioRxivPreprintMar 25, 2024

Mutational synergy with CREBBP loss in lymphomagenesis identified through forward insertional mutagenesis in a new DLBCL mouse model

Nathalie Sakakini, Roy Straver, Dhoyazan Azazi…·Brian J.P. Huntly

DOI 10.1101/2024.03.25.586554

mouseexperimental assay

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