Author

Sylke Hoehnel

École Polytechnique Fédérale de LausanneORCID 0000-0001-8449-1692Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Krisztián HomicskóiD· 2 shared Matthias P. LütolfiD· 2 shared Nathalie BrandenbergiD· 2 shared Nicolas BroguièreiD· 2 shared Alfonso Martínez AriasiD· 1 shared Antonia DigkliaiD· 1 shared Bart DeplanckeiD· 1 shared Bastien Mercier· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

Krisztián HomicskóORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintFeb 13, 2026

Deciphering spatial heterogeneity of patient-derived organoids of colorectal tumors for drug discovery

Maxim N. Norkin, Jonathan Bac, Louis McConnell…·Krisztián Homicskó

This study develops a platform to analyze spatial heterogeneity in colorectal tumor organoids using spatial transcriptomics and validates it against single-cell and tumor spatial data.

DOI 10.64898/2026.02.10.704651

humanspatial transcriptomics

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Cancer BiologybioRxivPreprintNov 1, 2023

Dissection and reconstruction of the colorectal cancer tumor microenvironment

Nicolas Broguière, Luis Francisco Lorenzo Martín, Simone Ragusa…·Matthias P. Lütolf

This study reconstructs the colorectal cancer tumor microenvironment using patient-derived organoids and co-cultures, revealing how stromal cells influence cancer behavior and immune evasion.

5 citations

humanscRNA-seq

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Developmental BiologyNature CommunicationsPeer-reviewedAug 26, 2021

Bioengineered embryoids mimic post-implantation development in vitro

Mehmet Girgin, Nicolas Broguière, Sylke Hoehnel…·Matthias P. Lütolf

This study develops EpiTS embryoids, which mimic post-implantation development in vitro by combining ESC and TSC aggregates to model gastrulation and axial morphogenesis.

67 citationstop 4%

mouseexperimental assay

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