Nicolas Broguière

This paper develops bioengineered human colon organoids that mimic in vivo complexity and function, enabling long-term study of gut physiology and disease.

This study reconstructs the colorectal cancer tumor microenvironment using patient-derived organoids and co-cultures, revealing how stromal cells influence cancer behavior and immune evasion.

This study develops EpiTS embryoids, which mimic post-implantation development in vitro by combining ESC and TSC aggregates to model gastrulation and axial morphogenesis.

This study develops a method to generate gastruloids with anterior neural tissues by inhibiting WNT signaling in mouse ESCs without exogenous Wnt activation.

This paper demonstrates that mouse embryonic stem cells can generate heart-like structures with in vivo-like morphogenesis, supporting cardiovascular progenitors and early heart field compartments.