Juraj Michalik

The paper shows that prior antigen exposure redirects CD8 T-cell activation programs, shaping progeny fate and persistence through distinct stemness and effector programs in naive and memory cells.

This study establishes a mouse model of Experimental Autoimmune Adrenalitis (EAA) and identifies IFNG-producing CD4+ T cells as key drivers of autoimmune adrenalitis.

This study shows that TANK and AZI2 prevent excessive inflammation by limiting Treg expansion and RIPK1-mediated cell death.

The paper identifies reduced effector and cytotoxic T-cell gene expression in early type 1 diabetes across multiple T-cell subsets using single-cell transcriptomics and flow cytometry.

This study shows that LCK deficiency in CD8 T cells reduces proliferation but increases effector T-cell formation in mice, revealing its dual role in T-cell responses.

This study identifies ABIN1 as a negative regulator of effector functions in cytotoxic T cells, showing its role in suppressing NF-κB and p38 pathways.