Ondřej Štěpánek

The paper shows that prior antigen exposure redirects CD8 T-cell activation programs, shaping progeny fate and persistence through distinct stemness and effector programs in naive and memory cells.

This study establishes a mouse model of Experimental Autoimmune Adrenalitis (EAA) and identifies IFNG-producing CD4+ T cells as key drivers of autoimmune adrenalitis.

This paper describes a method to co-isolate AAV with extracellular vesicles for efficient genome editing in rodent embryos, achieving higher viability and targeting efficiency compared to traditional purification methods.

This study shows that TANK and AZI2 prevent excessive inflammation by limiting Treg expansion and RIPK1-mediated cell death.

The paper shows that CMTM6 suppresses FAS expression in mice but not humans, highlighting species differences in CMTM6-FAS interaction.

The paper identifies reduced effector and cytotoxic T-cell gene expression in early type 1 diabetes across multiple T-cell subsets using single-cell transcriptomics and flow cytometry.

This study shows that LCK deficiency in CD8 T cells reduces proliferation but increases effector T-cell formation in mice, revealing its dual role in T-cell responses.

The study identifies Claudin 1 on DC1s as essential for their positioning near mTECs, facilitating antigen transfer and DC1 maturation, which maintains central tolerance.

This study shows that enhanced RNAi in mice does not improve antiviral immunity in vivo, but may work in vitro under specific conditions.

This study identifies ABIN1 as a negative regulator of effector functions in cytotoxic T cells, showing its role in suppressing NF-κB and p38 pathways.

This study investigates immune and hematopoietic system alterations in Bardet-Biedl Syndrome patients and a mouse model, finding increased autoimmune disease incidence, elevated white blood cell counts, and B cell abnormalities.