Renata B. Filler

This study shows that intranasal vaccination with a synthetic spike protein and adjuvants elicits durable mucosal IgA and protects against zoonotic SARS-like coronaviruses.

This paper develops a novel microporous biomaterial vaccine platform, VaxMAP, which enhances antibody-mediated immunity against viral infections compared to traditional vaccines.

The study surveys white-footed mice in Connecticut, finding low SARS-CoV-2 seroprevalence and identifying two divergent betacoronaviruses.

This study shows that SARS-CoV-2 variants differ in syncytia formation, which affects host chromatin accessibility, cellular senescence, and inflammation via TP53.

A genome-wide CRISPR screen with SARS-CoV-2 recovers ACE2 and Cathepsin L and nominates SWI/SNF, TGF-beta signalling and HMGB1 as pro-viral; pathway inhibitors blocked virus-induced death.

Time-course single-cell RNA sequencing of infected human bronchial epithelial cultures reports ciliated cells as a major target, with tropism later widening to basal and club cells.