Kashish Jain

This study shows ECM stiffness enhances EGFR signaling through integrin-mediated membrane curvature and topography, affecting RTK signaling across scales and potentially explaining resistance to tyrosine kinase inhibitors.

This study shows that progerin-induced senescent cells are eliminated by normal cells through mechanical competition and JNK/p38-MAPK pathways, while p16-induced senescent cells resist elimination.

This study shows that nanoclusters of integrins organize phosphorylated FAK nanoclusters in focal adhesions, which are required for mechanosignalling and disassemble in response to inactivation signals.

This paper introduces a single-construct optogenetic tool to control talin dimerization, enabling precise manipulation of mechanotransduction in integrin-based adhesions.

The paper shows that integrin nanoclusters self-organize within focal adhesions at an optimal distance to enable mechanotransduction, with cytoplasmic factors like talin and FHOD1 playing key roles.