Ken Inoki

This study shows that AMPK is not essential for normal podocyte function but is critical for preventing glomerular fibrosis in diabetes.

This study shows that mTOR hyperactivity in STRADA-deficient brain organoids causes delayed neurogenesis and altered interneuron fate, which can be rescued by rapamycin.

This study shows HUWE1 enhances mTORC1 activity by promoting Rheb interaction with mTORC1 and supports de novo pyrimidine synthesis via CAD activation.

This study shows PERK signaling promotes HSC proliferation under ER stress to maintain stem cell pool integrity by activating mTOR, without relying on apoptosis.

This study shows that endothelial ANGPTL4 depletion prevents diabetic kidney disease by improving metabolic function and reducing inflammation.

This study identifies Angptl4 as a fibrogenic molecule in diabetic kidney disease and shows that targeting its expression in kidneys reduces fibrosis and proteinuria.

This study shows that SCD1 and monounsaturated lipids are essential for autophagy and survival of adipocytes, with SCD1 deficiency causing autophagosome accumulation and cell death.