Author

Lynette Nel

Aarhus UniversityORCID 0000-0001-8980-5080Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:yeast· 2 Assay:cryo-EM· 1 Assay:structural biology· 1

Frequent Co-Authors

Bjørn Panyella PederseniD· 2 shared Daniel WüstneriD· 2 shared Esben OleseniD· 2 shared Katja ThayseniD· 2 shared Kelly May FrainiD· 2 shared Anastasiia BohushiD· 1 shared David L. StokesiD· 1 shared Denisa JamecnaiD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersBiophysics

Bjørn Panyella PedersenORCID

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2 papers

Recent·Most cited

BiophysicsLife Science AlliancePeer-reviewedOct 25, 2024

Structural and biochemical analysis of ligand binding in yeast Niemann-Pick type C1-related protein

Lynette Nel, Katja Thaysen, Denisa Jamecna…·Bjørn Panyella Pedersen

This study investigates the lipid binding properties of the yeast NCR1/NPC2 system using crystal structures and binding assays, revealing its ability to bind multiple lipids beyond sterols.

5 citations

yeaststructural biology

𝕏 PostBluesky

BiochemistrybioRxivSep 8, 2023

Conformational changes in the Niemann-Pick Type C1 protein NCR1 drive sterol translocation

Kelly M. Frain, Emil Dedic, Lynette Nel…·Bjørn Panyella Pedersen

This study identifies a glycocalyx in yeast vacuoles and presents cryo-EM structures of NCR1 showing conformational changes that drive sterol translocation across the glycocalyx.

DOI 10.1073/pnas.2315575121

yeastcryo-EM

𝕏 PostBluesky