Sin Man Lam

The paper identifies a senescent-like muscle stem cell subpopulation that drives muscle regeneration through secretory activity and cell communication.

The paper identifies PI4P's role in recruiting SNAP47 to facilitate SNARE-dependent AMPAR exocytosis during synaptic potentiation.

This study identifies lithocholic acid as a metabolite that mimics calorie restriction's anti-aging effects in multiple species through AMPK activation.

This study identifies focal adhesions as the subcellular hubs organizing PI3K-PI(3,4,5)P3-AKT signaling, showing localized lipid production and AKT activation, and demonstrates that combined inhibition of PI3K and FAK enhances cancer cell suppression.

The paper identifies nhr-114 and spin-4 as suppressors of seip-1 embryonic lethality in C. elegans, showing that reducing phosphatidylcholine synthesis suppresses lethality but worsens lipid droplet abnormalities.

This study shows that IVF disrupts placental lipid metabolism, leading to intrauterus growth restriction and low birth weight by altering gene expression and imprinting status.