Bente Siebels

This study identifies EF-Tu as a target of the Fic enzyme SoFic, showing AMPylation disrupts EF-Tu's switch-I region and inhibits translation, while SoFic also binds DNA, suggesting dual regulatory roles.

This study characterizes the multi-omics profile of extracellular vesicles from MCPyV-positive Merkel cell carcinoma cells, revealing distinct molecular cargo and pathway enrichment.

This study maps the molecular changes in murine upper-layer cortical neurons during development and shows how maternal immune activation disrupts this process through post-transcriptional and signaling mechanisms.

The paper integrates kidney and urine proteomics with peptidomics and machine learning to identify encrypted antimicrobial peptides as functional effectors in human pyelonephritis.

This study identifies lactate as a metabolic driver of CD163+ macrophage polarization in human pyelonephritis, linking lactate metabolism to immune dysfunction.

This study uses integrative multi-omics analysis to identify disease-associated molecular signatures in lung and muscle tissues of harbour porpoises with poor respiratory health.

This study shows that neutralizing extracellular histones reduces secondary brain injury and improves recovery after ischemic stroke complicated by pneumonia.

This paper identifies AnkX as a Legionella effector that posttranslationally modifies IMPDH2, disrupting its filament assembly and altering GTP metabolism in host cells.

The paper identifies TSP1/TGF-β1 as a key driver of neutrophil swarming through arachidonic acid metabolism in a urinary tract infection model.

OmixLitMiner 2 automates literature mining to categorize marker candidates by their literature coverage, improving efficiency in omics data interpretation.

This paper develops and validates an optimized workflow for isolating and characterizing extracellular vesicle subsets from diverse sources using FACS and imaging techniques.

This study shows that extracellular vesicles from cortical neurons alter spontaneous activity in recipient neurons by increasing postsynaptic potential amplitude.

This study shows that heart muscle cell contractility suppresses proliferation and that inhibiting it allows cell cycle re-entry, suggesting contractility as a key regulator of cardiac regeneration.

The paper identifies monoallelic PSMB8 variants causing impaired immunoproteasome assembly and a novel PRAAS subtype with immunodeficiency.

This study identifies chaperone-independent outer membrane proteins in Shewanella oneidensis and shows MtrA assists in MtrB folding, challenging the role of canonical chaperones.

This study shows that red blood cells from cancer patients enhance tumour cell invasiveness and metastatic potential through gene and protein changes, suggesting PAK4 as a therapeutic target.

This paper demonstrates that non-enzymatic methods can isolate brain-derived extracellular vesicles without compromising protein integrity, achieving high yield and purity.

This study identifies proteomic adaptations in human pyelonephritis, revealing elevated antimicrobial peptides and their potential protective role against systemic inflammation.