Devon Siemes

The paper integrates kidney and urine proteomics with peptidomics and machine learning to identify encrypted antimicrobial peptides as functional effectors in human pyelonephritis.

This study identifies lactate as a metabolic driver of CD163+ macrophage polarization in human pyelonephritis, linking lactate metabolism to immune dysfunction.

This study shows that neutralizing extracellular histones reduces secondary brain injury and improves recovery after ischemic stroke complicated by pneumonia.

The paper identifies TSP1/TGF-β1 as a key driver of neutrophil swarming through arachidonic acid metabolism in a urinary tract infection model.

The paper shows SCAMP3 is essential for neutrophil granule formation and function, with Scamp3-deficient neutrophils showing impaired bacterial killing in vitro.

The paper shows that thyroid hormone and resmetirom have harmful extrahepatic effects in white adipose tissue that counteract their beneficial effects on the liver in alcohol-associated liver disease in mice.

msiFlow automates and streamlines multimodal mass spectrometry imaging and immunofluorescence data analysis to enhance reproducibility and scalability in biological research.

This study shows that thyroid hormone-induced cardiac hypertrophy relies on noncanonical TR action, while heart rate regulation depends on canonical TR action, with TRβ compensating for TR absence.

This study identifies proteomic adaptations in human pyelonephritis, revealing elevated antimicrobial peptides and their potential protective role against systemic inflammation.

VesselExpress automates 3D blood vasculature analysis in LSFM data, enabling rapid and unbiased quantification of vascular parameters across multiple organs.