Rhys H. Parry

The paper investigates the role of Argonaute in controlling viral replication in Leishmania martiniquensis, finding that its loss reduces viral RNA abundance and disrupts small RNA accumulation.

The paper shows how SARS-CoV-2 variants, particularly Omicron, evolved proteolytic controls at the Spike furin cleavage site to enhance transmission while reducing lower respiratory tract pathogenicity.

sRNAMap is a browser-based tool for analyzing and visualizing small RNA sequencing data, offering alignment, coverage, and feature quantification with high concordance to existing methods.

The paper optimizes reverse genetics methods for positive-sense RNA viruses, showing improved recovery efficiency using specific promoters and ribozymes.

This study identifies Dicer-like 1 and Argonaute 1 as critical for controlling viral RNA levels in Leishmania guyanensis via a canonical RNA interference pathway.

The paper establishes classification criteria for jingmenviruses using genomic sequences from metagenomics data to define species demarcation thresholds.

The paper maps the geographic distribution and host associations of MaRNAV-1, a virus linked to Plasmodium vivax, using metatranscriptomic data.

This study identifies how cytomegalovirus infection reprograms murine dendritic cells to suppress MHC class II antigen presentation while enhancing migration machinery, with M33 specifically boosting migration-related genes.

This study compares SARS-CoV-2 Omicron variants' effects on nasal epithelial ciliated cells, finding increased tropism and dysfunction in BA.5 and XBB compared to BA.1 and ancestral virus.

The paper evaluates vaccine-induced and hybrid immunity against SARS-CoV-2 variants in two cohorts, finding reduced antibody titres and neutralization activity against Omicron variants, with some recovery after multiple vaccinations.

This study shows that SFTSV NSs protein is essential for viral replication in tick cells by suppressing the tick's RNAi response through depletion of virus-derived siRNAs.

The paper identifies a novel Rickettsia species and DNA viruses in Australian ticks using metagenomics and models Rickettsia exposure zones.

This paper shows that SARS-CoV-2 Omicron lineages replicate using a specific ACE2 pool that does not complex with TMPRSS2, unlike pre-Omicron variants.

The paper analyzes tunicate metatranscriptomes to show that some disease-causing RNA viruses evolved before vertebrates and that recombination between viral orders shaped their evolution.

This paper develops a bispecific antibody that targets both Nipah virus surface glycoproteins, reducing viral escape and enhancing protection against NiV disease.

This study identifies the PAZ domain's role in ensuring accurate 21 nt vsiRNA production by Dcr2 in Aedes aegypti, critical for antiviral responses against Semliki Forest virus.

The paper identifies three novel jingmenviruses with up to six genomic segments and proposes mechanisms for their translation, contributing to understanding their multipartite genomic organization.

This paper identifies a 39.8kb flavi-like virus without an exonuclease that overcomes the RNA virus error threshold by using bacterial nucleic acid metabolism domains.

The paper identifies a novel papillomavirus, AfPV1, in New Zealand fur seals with oral papilloma-like lesions and detects a novel gammaherpesvirus, AfGHV1, in another individual.

This study shows senolytic drugs reduce brain aging and COVID-19-related neuropathology by targeting senescent cells in human brain organoids and mice.

The paper shows Omicron SARS-CoV-2 lineages rely on ACE2 without TMPRSS2 complexes for entry, due to changes in the ACE2 Collectrin-Like Domain affecting TMPRSS2 activation.

This study shows SARS-CoV-2 activates microglial NLRP3 inflammasome via spike-ACE2 interaction, potentially linking viral infection to neurological symptoms like Parkinson's.